Joseph Irudayaraj


Professor of Biological Engineering
Chair, ABE Graduate Program
Purdue University


  • Biomedical
    • Detection of in vivo phophorylation using surface enhanced Raman spectroscopy (SERS). Irudayaraj and Parker (Medicinal Chemistry and Molecular Pharmacology)
    • In vivo detection of double DNA breaks in living cells. Irudayaraj and Lelievre (BMS)
    • Reverse Electrokinetic Pattering in biology: Motility studies, Chorum sensing, and cell sorting. Steve Worley (ME) and Irudayaraj.
    • Epigenetics Research
      • In vivo epigenetics tools development. Irudayaraj, Kirchmaier (BCHM), Lossie (Animal Sciences).
      • Single molecule tools for examining histone modifications in living cells. Kirchmaier (Biochemistry) and Irudayaraj.
      • Quantification of epigenetic modifications in 3D tissue culture models. Lelievre (BMS) and Irudayaraj
    • In vivo detection mRNA and microRNA in single cells and tissues by plasmon imaging. Irudayaraj, Badve (Clarion IU School of Medicine) and Kirchmaier (BCMH)
    • Indo-US Center for Cellular Engineering for biomedical research. Irudayaraj and Rao, CCMB (Hyderabad, India) [Dr. Irudayaraj and Rao are Co-directors]
  • Environment
    • Bioremediation: Mapping chromate/Arsenate reduction sites in single bacterium by SERS. Irudayaraj, Nakatsu (AGRY), and Thompson (Biological Sciences, University of Tennessee)
    • Detection of rare splice variants in plants using Confocal Raman Spectroscopy. Irudayaraj and Schulz (HLA)
    • Pathogen detection spectroscopic biosensors. Irudayaraj and Mauer (Food Science)
  • Instrumentation
    • Development of a hyperspectral plasmon scanning workstation. Irudayaraj
    • Major research instrumentation for the development of high speed Raman instrumentation. Ben-Amotz (Chemistry) and Irudayaraj.
    • Probe-based single molecule fluorescence correlation spectroscopy. Maiti (TIFR, India) and Irudayaraj
    • Major research instrumentation for the acquisition of multiphoton laser for ultrafast dynamics. Lucht (Mechanical Engineering), Irudayaraj, and 3 other Co-PIs.
    • Development of a label-free single molecule platform for imaging structures in single cells. Irudayaraj.
  • International Projects
    • Indo-US Center for Cellular Engineering for biomedical research. Irudayaraj and Rao, CCMB (Hyderabad, India)
    • Tumor ablation enhanced by nanorods using radio frequency. Irudayaraj and Ganesh (MG Ramachandra Medical College, Chennai, India)
    • Korean Institute of Science and Technology (KIST) on Nanomedicine
      1. Lee, K., Drachev, V., and Irudayaraj, J. 2011. DNA-Gold Nanoparticle Networks Grown at Cell Surface Marker Sites: Application in Diagnostics of Cancer Stem Cells. ACS NANO (Article ASAP DOI: 10.1021/nn1030862).
      2. Wang, Y. and Irudayaraj, J. 2011. A SERS DNAzyme Biosensor for Lead Ion Detection. Chemical Communications (accepted).
      3. Chen, J., Nag, S., and Irudayaraj, J. 2011. Single molecule in vivo analysis of Toll-like 9 and CpG DNA interaction. PLoS ONE (In Press).
      4. Guo, C. and Irudayaraj, J. 2011. Fluorescent Ag Clusters via a Protein-directed Approach as a Hg(II) Ion Sensor. Analytical Chemistry (accepted).
      5. Ravindranath, S., Wang, Y., Irudayaraj, J. 2010. SERS driven Cross-platform based multiplex pathogen detection. Sensors & Actuators: B. Chemical. (Final proof is available online doi:10.1016/j.snb.2010.12.005).
      6. Wang, Y., Ravindranath, S., and Irudayaraj, J. 2010. Separation and detection of multiple pathogens in a food matrix by SERS nano probes. Analytical and Bioanalytical Chemistry. (Final proof available online, ISSN: 1618-2650)
      7. Ravindranath, S., Henne, K., Thompson, D., and Irudayaraj, J. 2011. Surface-enhanced Raman Imaging of Intracellular Bioreduction of Chromate in Shewanella oneidensis. PLoS ONE (Published

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